Antimicrobial and hypoglycemic effects of Elaeocarpus Ganitrus Seed
Keywords:
Antibacterial, Antifungal, Hypoglycemic, Elaeocarpus Ganitrus.Abstract
The Evaluation of the antibacterial, antifungal and hypoglycemic effects of methanol and water (ratio70:30) extract of Elaeocarpus Ganitrus seeds were investigated by using the cup bore agar diffusion method and hypoglycemic effect was evaluated in alloxan induced diabetic rats. The extract of E.Ganitrus seed significantly inhibited Bacillus subtilis, Staphylococcus aureus (Gram positive), Klebsiella pneumonia, Escherichia coli, Salmonella typhi, Proteus vulgaris and Pseudomonas aeruginosa (Gram-negative) to varying degrees, but it had little inhibitory effect on fungal species (Aspergillus niger, Aspergillus fumigatus, Mucor pusillus (fungi), and Candida albicans (yeast).For anti bacterial study Gentamycin, the standard antibacterial drug used for inhibiting these bacteria. The effect on B.  subtilis and E. coli were similar to that of gentamycin. Ketoconazole, the regular ant fungicide used was effective against all the fungi and yeast species. The extract of E.Ganitrus seed also significantly (P<0.05) reduced blood glucose level in alloxan induced diabetic rats twelve hours after administration. The effect of the extract at 1000mg/kg was comparable to that of the standard drug (chlorpropamide) used. Results support some of the traditional uses of E.Ganitrus seed as an anti-infective herb and for the management of diabetic sores
References
2. Dasgupta A., Agrawal S. S , and Basu D. K. (1984) .Anticonvulsant activity of the mixed fatty acids of the Elaeocarpus ganitrus Roxb.Indian J of Phyiolo. Pharmacology. 28. 245-286.
3. Bhattacharya S.K., Debnath P. K., Pandey V. B. and Sanyal A. K. (1975) .Pharmacologicalinvestigation on Elaeocarpus ganitrus, PlantaMed.. 23. 174–177.
4. Pandey V. B and Bhattacharya S. K. (1985). Scientific appraisal of rudraksha (Elaeocarpus ganitrus): chemical and pharmacological studies.J. Res. Educ. Indian Med. Jan-June, 47–50.
5. Rao K. Srikanth, Rao O Umamaheswar, Aminabee SK, Rao CH, Ram Mohan and Rao A. Lakshmana. (2012). Hypoglycemic and Antidiabetic potential of chitosan aqueous extract of Elaeocarpus ganitrus. 2(2). 2231-81
6. Dalei J And Sahoo D.(2016). Evaluation Of Antimicrobial Activity And Phytochemical Screening Of Epicarp And Endocarp Parts Of Elaeocarpus Ganitrus. Int J Pharm Bio Sci April. 7(2). (P) 265 – 269
7. http://www.rudraksha-life.com/topic/31-ayurvedic-properties-of-rudraksha.aspx
8. http://ttktamop.elte.hu/online-tananyagok/practical_microbiology/ch06s02.html.
9. Irobi ON and Daranola SO.(1994). Bactericidal properties of crude extract of racarpu villosus. J.Ethnopharmacol. 42.39-43.
10. Collins, C.H., Lynes, P.M and Grange, J.M. (1995).Microbiological Methods (7th edition). Butterwort-Heinemann Ltd, Britain.pp.175-190.
11. Singh R.K., Nath G .(1999) Antimicrobial activity of Elaeocarpus sphaericus. Phytother Res.13.448–450
12. http://www.himedialabs.com/TD/M075.pdf
13. Singh B., Chopra A., Ishar M.P.S., Sharma A., Raj T., Pharmacognostic and antifungal investigations of Elaeocarpus ganitrus (Rudrakasha). Indian J Pharma Sci, 72(2):261–265, (2010)
14. Hule AK , Shah AS , Gambhire MN, Juvekar AR(2011). An evaluation of the antidiabetic effects of Elaeocarpus ganitrus in experimental animals. Indian J pharmacol, 43: 56-59.
15. Sakat SS, Wankhede SS, Juvekar AR, Mali VR, Bodhankar SL, Antihypertensive activity of aqueous extract of Elaeocarpus ganitrus Roxb. Seeds in renal artery occluded hypertensive rats, International Journal of Pharma Tech Research, 1, 2009, 779-782.
16. AB Saba, AA Oyagbemi, and OI Azeez Antidiabetic and haematinic effects of Parquetina nigrescens on alloxan induced type-1 diabetes and normocytic normochromic anaemia in Wistar rats Afr Health Sci. 2010 Sep; 10(3): 276–282.
